Publications | Salem Lab

† Corresponding author/ study supervisor

* Equal contribution

1) Metsäniitty, M. A., Hasnat, S., Öhman, C., Eklund, K. K., Oscarsson, J. & Salem A†. Extracellular vesicles from Aggregatibacter actinomycetemcomitans exhibit potential antitumorigenic effects in oral cancer: A comparative in vitro study.Arch Microbiol. 2024;206(6):244. Published 2024 May 3. doi:10.1007/s00203-024-03976-8

2) Metsäniitty, M., Hasnat, S., Öhman, C., Salo, T., Eklund, K. K., Oscarsson, J., & Salem, A. (2024). Zebrafish larvae as a model for studying the impact of oral bacterial vesicles on tumor cell growth and metastasis. Human cell, 10.1007/s13577-024-01114-6.

3) Hujanen R, Salo T, Eklund KK, & Salem A†. Ex Vivo Evaluation of Antiangiogenic Drugs in Oral Cancer: Potential Implications for Targeting Vasculogenic Mimicry. Anticancer Res. 2024;44(6):2377-2392. doi:10.21873/anticanres.17045

4) Salem, A., Zakham, F., Kirschenmann, H. & Cambou, D. Students Perceptions of Assessment and Its Potential Effect on Learning and Study Motivation: A Trial Study at the University of Helsinki. 1 Aug 2023, (In preparation) In: Education Sciences.

5) Salem A†, Salo, T. Identity matters: cancer stem cells and tumour plasticity in head and neck

squamous cell carcinoma. Expert Rev Mol Med., 25:e8. 2023. doi:10.1017/erm.2023.4

6) Karinen S, Hujanen R, Salo T, Salem A†. The prognostic influence of lymphatic endothelium- specific hyaluronan receptor 1 in cancer: A systematic review. Cancer Sci., 113:17-27, 2022. doi:10.1111/cas.15199.

7) Karinen S, Juurikka K, Hujanen R, Wahbi W, Hadler-Olsen E, Svineng G, Eklund KK, Salo T, Åström P, Salem A†. Tumour cells express functional lymphatic endothelium-specific hyaluronan receptor in vitro and in vivo: Lymphatic mimicry promotes oral oncogenesis? Oncogenesis, 5;10:23, 2021 doi:10.1038/s41389-021-00312-3

8) Hujanen R, Almahmoudi R, Salo T, Salem A†: Comparative Analysis of Vascular Mimicry in Head and Neck Squamous Cell Carcinoma: In Vitro and In Vivo Approaches. Cancers., 13(19):4747, 2021. doi:10.3390/cancers13194747

9) Metsäniitty M, Hasnat S, Salo T, Salem A†. Oral Microbiota-A New Frontier in the Pathogenesis and Management of Head and Neck Cancers. Cancers (Basel), 14:46, 2021. doi:10.3390/cancers14010046

10) Almahmoudi R, Salem A, Hadler-Olsen E, Svineng G, Salo T, Al-Samadi A. The effect of interleukin-17F on vasculogenic mimicry in oral tongue squamous cell carcinoma. Cancer Sci., 112:2223-2232, 2021. doi:10.1111/cas.14894

11) Hasnat S, Hujanen R, Nwaru BI, Salo T, Salem A†: The Prognostic Value of Toll-Like Receptors in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis. Int J Mol Sci., 21:E7255, 2020. doi:10.3390/ijms21197255

12) Hujanen R, Almahmoudi R, Karinen S, Nwaru BI, Salo T, Salem A†. Vasculogenic Mimicry: A Promising Prognosticator in Head and Neck Squamous Cell Carcinoma and Esophageal Cancer? A Systematic Review and Meta-Analysis. Cells, 9:507, 2020. doi:10.3390/cells9020507

13) Salem A†, Almahmoudi R, Hagström J, Stark H, Nordström D, Salo T, Eklund KK. Human β- Defensin 2 Expression in Oral Epithelium: Potential Therapeutic Targets in Oral Lichen Planus. Int J Mol Sci., 20.pii: E1780, 2019. doi:10.3390/ijms20071780

14) Salem A†, Almahmoudi R, Listyarifah D, Siponen M, Maaninka K, Al-Samadi A, Salo, T, Eklund KK. Histamine H4 receptor signalling in tongue cancer and its potential role in oral carcinogenesis. Cell Oncol., 40:621-630, 2017. doi:10.1007/s13402-017-0336-6

15) Salem A†, Rozov S, Al-Samadi A, Stegajev V, Listyarifah D, Kouri VP, Han X, Nordström D, Hagström J, Eklund KK. Histamine metabolism and transport are deranged in human keratinocytes in oral lichen planus. Br J Dermatol., 176:1213-1223, 2017. doi:10.1111/bjd.14995

16) Salem A†, Salo T. Vasculogenic Mimicry in Head and Neck Squamous Cell Carcinoma—Time to

Take Notice. Front Oral Health., 2:666895, 2021. doi:10.3389/froh.2021.666895

17) Salem A†, Hadler-Olsen E, Al-Samadi A. Editorial: Angiogenesis and Angiogenesis Inhibitors in

Oral Cancer. Front Oral Health., 2:816963, 2021. doi:10.3389/froh.2021.816963

18) Frejborg E, Salo T, Salem A†. Role of Cyclooxygenase-2 in Head and Neck Tumorigenesis. Int J Mol

Sci., 21:9246, 2020. doi:10.3390/ijms21239246

19) Salem A†, Salo T. Nothing to sneeze at: Histamine and histamine receptors in oral carcinogenesis.

Oral Dis., 27:1090-1096, 2021. doi:10.1111/odi.13411

20) Salem A†, Salo T. Commentary: Pathophysiological Role of Histamine H4 Receptor in Cancer:

Therapeutic Implications. Front Pharmacol., 11:874, 2020. doi:10.3389/fphar.2020.00874

21) Vehviläinen M*, Salem A*, Asghar MY, Salo T, Siponen M: No detection of TSH or TSHR in oral lichen planus lesions in patients with or without hypothyroidism. Acta Odontol Scand., 78:337-344, 2020. doi:10.1080/00016357.2020.1720798

22) Wahab A, Hyytiäinen A, Wahbi W, Tuomainen K, Tervo S, Conesa-Zamora P, Jauhiainen L, Mäkinen LK, Paavonen T, Toppila-Salmi S, Salem A, Almangush A, Salo T, Al-Samadi A. The effect of fascin 1 inhibition on head and neck squamous cell carcinoma cells. Eur J Oral Sci., 129:e12819, 2021. doi:10.1111/eos.12819

23) Almahmoudi R, Salem A, Murshid S, Dourado MR, Apu EH, Salo T, Al-Samadi A. Interleukin-17F Has Anti-Tumor Effects in Oral Tongue Cancer. Cancers (Basel)., 11. pii: E650., 2019. doi:10.3390/cancers11050650.

24) Al-Samadi A, Tuomainen K, Kivimäki A, Salem A, Al-Kubati S, Hyytiäinen A, Parikka M, Mesimäki K, Wilkman T, Mäkitie A, Grenman R, Salo T. PCR-based zebrafish model for personalised medicine in head and neck cancer. J Transl Med., 17:235, 2019. doi:10.1186/s12967- 019-1985-1

25) Almahmoudi R, Kasanen M, Sieviläinen M, Salem A, Pirinen M, Salo T, Al-Samadi A. The Prognostic Value of Blood and Lymphatic Vessel Markers in Tongue Cancer: A Systematic Review. Cancer Sci., 10: 3424-3433, 2019. doi:10.1111/cas.14189

26) Salem A†, Almahmoudi R, Vehviläinen M, Salo T. Role of the high mobility group box 1 signalling axes via the receptor for advanced glycation end-products and toll-like receptor-4 in the immunopathology of oral lichen planus: a potential drug target? Eur J Oral Sci., 126:244-248, 2018. doi:10.1111/eos.12416

27) Salem A, Al-Samadi A, Stegajev V, Stark H, Häyrinen-Immonen R, Ainola M, Hietanen J, Konttinen YT. Histamine H4 receptor in oral lichen planus. Oral Dis., 21:378-385, 2015. doi:10.1111/odi.12290

28) Salem A†, Mustafa R, Listyarifah D, Al-Samadi A, Barreto G, Nordström D, Eklund KK. Altered Expression of Toll-like Receptors in Human Oral Epithelium in Oral Lichenoid Reactions. Am J Dermatopathol. 39:811-818, 2017. doi:10.1097/DAD.0000000000000807

29) Almahmoudi R, Salem A†, Sieviläinen M, Sundquist E, Almangush A, Toppila-Salmi S, Paavonen T, Salo T, Al-Samadi A. Extracellular interleukin-17F has a protective effect in oral tongue squamous cell carcinoma. Head Neck. 40:2155-2165, 2018. doi:10.1002/hed.25207

30) Stegajev V, Kouri VP, Salem A, Rozov S, Stark H, Nordström DC, Konttinen YT. Activation of histamine H4 receptor inhibits TNFα/IMD-0354-induced apoptosis in human salivary NS-SV-AC cells. Apoptosis., 19:1702-1711, 2014. doi:10.1007/s10495-014-1036-6

31) Barreto G, Sandelin J, Salem A, Nordström DC, Waris E. Toll-like receptors and their soluble forms differ in the knee and thumb basal osteoarthritic joints. Acta Orthop., 88:326-333, 2017. doi:10.1080/17453674.2017.1281058

32) Al-Samadi A, Awadh S, Tuomainen K, Zhao Y, Salem A, Parikka M, Salo T. Crosstalk between tongue carcinoma cells, extracellular vesicles, and immune cells in in vitro and in vivo models. Oncotarget, 8:60123-60134, 2017. doi:10.18632/oncotarget.17768

33) Listyarifah D, Al-Samadi A, Salem A, Syaify A, Salo T, Tervahartiala T, Grenier D, Nordström DC, Sorsa T, Ainola M. Infection and apoptosis associated with inflammation in periodontitis: An immunohistologic study. Oral Dis. 23:1144-1154, 2017. doi:10.1111/odi.12711

34) Al-Samadi A, Moossavi S, Salem A, Sotoudeh M, Tuovinen SM, Konttinen YT, Salo T, Bishehsari F. Distinctive expression pattern of interleukin-17 cytokine family members in colorectal cancer. Tumour Biol., 37:1609-1615, 2016. doi:10.1007/s13277-015-3941-x

35) Al-Samadi A, Drozd A, Salem A, Hietanen J, Häyrinen-Immonen R, Konttinen YT. Epithelial Cell Apoptosis in Recurrent Aphthous Ulcers. J Dent Res., 94:928-935, 2015. doi:10.1177/0022034515581012

36) Al-Samadi A, Salem A, Ainola M, Hietanen J, Häyrinen-Immonen R, Konttinen YT. Increased beta 2 defensin in recurrent aphthous ulcer. Oral Dis., 21:292-298, 2015. doi:10.1111/odi.12262

37) Al-Samadi A, Kouri VP, Salem A, Ainola M, Kaivosoja E, Barreto G, Konttinen YT, Hietanen J, Häyrinen-Immonen R. IL-17C and its receptor IL-17RA/IL-17RE identify human oral epithelial cell as an inflammatory cell in recurrent aphthous ulcer. J Oral Pathol Med., 43:117-124, 2014. doi:10.1111/jop.12095

38) Barreto G, Sillat T, Soininen A, Ylinen P, Salem A, Konttinen YT, Al-Samadi A, Nordström DC. Do changing toll-like receptor profiles in different layers and grades of osteoarthritis cartilage reflect disease severity? J Rheumatol., 40:695-702, 2013. doi:10.3899/jrheum.121159

39) Nich C, Takakubo Y, Pajarinen J, Ainola M, Salem A, Sillat T, Rao AJ, Raska M, Tamaki Y, Takagi M, Konttinen YT, Goodman SB, Gallo J. Macrophages-Key cells in the response to wear debris from joint replacements. J Biomed Mater Res A., 101:3033-3045, 2013. doi:10.1002/jbm.a.34599
40) Konttinen YT, Salem A, Hietanen J: Hiivaa ja punajäkälää. Kuivakukat: Sjögrenin syndrooma -

yhdistyksen jäsenlehti. Kansainvälisiä vertaisarvioituja, 2013.